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    ergi-2 Endoplasmic reticulum-Golgi intermediate compartment protein 2 [ Caenorhabditis elegans ]

    Gene ID: 181597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ergi-2
    Official Full Name
    Endoplasmic reticulum-Golgi intermediate compartment protein 2
    Primary source
    WormBase:WBGene00007668
    Locus tag
    CELE_C18B12.6
    See related
    AllianceGenome:WB:WBGene00007668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Is expressed in anal depressor muscle; anal sphincter muscle; anterior distal tip cell; posterior distal tip cell; and tail neurons. Orthologous to human ERGIC2 (ERGIC and golgi 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ergi-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (15004058..15007308, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondrial glutamate carrier 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
    2. Identification of novel target genes of CeTwist and CeE/DA. Wang P, et al. Dev Biol, 2006 May 15. PMID 16480708
    3. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Endoplasmic reticulum-Golgi intermediate compartment protein 2
    NP_510494.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15004058..15007308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078093.8 → NP_510494.2  Endoplasmic reticulum-Golgi intermediate compartment protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510494.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEW1
      Conserved Domains (2) summary
      pfam07970
      Location:226 → 380
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:21 → 98
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
    Nucleotide Protein
    Heading Accession and Version

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