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    F10G7.10 E3 ubiquitin-protein ligase [ Caenorhabditis elegans ]

    Gene ID: 173813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F10G7.10
    Official Full Name
    E3 ubiquitin-protein ligase
    Primary source
    WormBase:WBGene00017373
    Locus tag
    CELE_F10G7.10
    See related
    AllianceGenome:WB:WBGene00017373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F10G7.10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    23
    Sequence:
    Chromosome: II; NC_003280.10 (4713674..4726161, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C3H1-type domain-containing protein Neighboring gene Staphylococcal nuclease domain-containing protein 1 Neighboring gene Pre-rRNA-processing protein TSR1 homolog Neighboring gene MARVEL domain-containing protein Neighboring gene Transthyretin-like family protein Neighboring gene Ovule protein;WD_REPEATS_REGION domain-containing protein Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase
    NP_001366635.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4713674..4726161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381399.3 → NP_001366635.1  E3 ubiquitin-protein ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MML0
      Conserved Domains (3) summary
      smart00396
      Location:138 → 207
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      cd16483
      Location:1322 → 1460
      RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
      pfam18995
      Location:1882 → 2010
      PRT6_C; Proteolysis_6 C-terminal
    Nucleotide Protein
    Heading Accession and Version

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