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    F54C8.7 AH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F54C8.7
    Official Full Name
    AH domain-containing protein
    Primary source
    WormBase:WBGene00010040
    Locus tag
    CELE_F54C8.7
    See related
    AllianceGenome:WB:WBGene00010040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phospholipid binding activity. Involved in IRE1-mediated unfolded protein response. Located in mitochondrion. Is expressed in pharynx. Orthologous to human ARFIP1 (ADP ribosylation factor interacting protein 1) and ARFIP2 (ADP ribosylation factor interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F54C8.7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (9451591..9454062, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTP-binding protein Rheb homolog 1 Neighboring gene Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AH domain-containing protein
    NP_001022604.1
    • Confirmed by transcript evidence
    NP_001254995.1
    • Confirmed by transcript evidence
    NP_001370276.1
    • Confirmed by transcript evidence
    NP_001379523.1
    • Confirmed by transcript evidence
    NP_001379524.1
    • Confirmed by transcript evidence
    NP_871661.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9451591..9454062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027433.7 → NP_001022604.1  AH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34445
      Conserved Domains (1) summary
      cd07660
      Location:74 → 274
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    2. NM_001382962.2 → NP_001370276.1  AH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6R3
      Conserved Domains (1) summary
      cd07660
      Location:56 → 256
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    3. NM_001392175.1 → NP_001379524.1  AH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6R5
      Conserved Domains (1) summary
      cl12013
      Location:1 → 140
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. NM_181932.7 → NP_871661.1  AH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34445, Q86D24
      Conserved Domains (1) summary
      cd07660
      Location:93 → 293
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    5. NM_001392174.1 → NP_001379523.1  AH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6R4
      Conserved Domains (1) summary
      cd07660
      Location:9 → 209
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    6. NM_001268066.3 → NP_001254995.1  AH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1MN62
      Conserved Domains (1) summary
      cd07660
      Location:43 → 243
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34445.3

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