peb-1 FLYWCH-type zinc finger-containing protein peb-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: peb-1
Official Full Name: FLYWCH-type zinc finger-containing protein peb-1
Primary source: WormBase:WBGene00003968
Locus tag: CELE_T14F9.4
See related: AllianceGenome:WB:WBGene00003968
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including germ line; pharynx; rectal epithelial cell; seam cell; and tail hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See peb-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (2211051..2218988)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both the FLYWCH motif and the C-terminal domain are required for efficient nuclear localization, suggesting PEB-1 must bind DNA and other components to remain in the nucleus
Title: DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif.
Results describe the deletion mutant peb-1 that results in penetrant larval lethality characterized by defects in pharyngeal function and molting.
Title: C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T14F9.4 (e-PCR)
- UniSTS:310847

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FLYWCH-type zinc finger-containing protein peb-1

NP_001024910.1

Confirmed by transcript evidence

NP_001364564.1

Confirmed by transcript evidence

NP_001364745.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2211051..2218988

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001377612.2 → NP_001364564.1 FLYWCH-type zinc finger-containing protein peb-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A5S9MMK5, H2KZM4, Q7Z1Q1, Q9U9Q9

Conserved Domains (1) summary

pfam04500
Location:69 → 135

FLYWCH; FLYWCH zinc finger domain
NM_001029739.6 → NP_001024910.1 FLYWCH-type zinc finger-containing protein peb-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024910.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZM4

Conserved Domains (1) summary

pfam04500
Location:53 → 119

FLYWCH; FLYWCH zinc finger domain
NM_001377613.2 → NP_001364745.1 FLYWCH-type zinc finger-containing protein peb-1 [Caenorhabditis elegans]

Status: REVIEWED