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    K02F3.12 Putative ATP-dependent DNA helicase Q1 [ Caenorhabditis elegans ]

    Gene ID: 175246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    K02F3.12
    Official Full Name
    Putative ATP-dependent DNA helicase Q1
    Primary source
    WormBase:WBGene00019334
    Locus tag
    CELE_K02F3.12
    See related
    AllianceGenome:WB:WBGene00019334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to be located in nucleus. Predicted to be active in chromosome and cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See K02F3.12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (856560..860090)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Exoribonuclease phosphorolytic domain-containing protein Neighboring gene putative actin-related protein 2/3 complex subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA geometric change IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative ATP-dependent DNA helicase Q1
    NP_001022656.1
    • Confirmed by transcript evidence
    NP_001022657.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      856560..860090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027485.3 → NP_001022656.1  Putative ATP-dependent DNA helicase Q1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5DX50, Q9TXJ8
      Conserved Domains (4) summary
      TIGR00614
      Location:99 → 571
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd00079
      Location:303 → 435
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:111 → 281
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:440 → 496
      RecQ_Zn_bind; RecQ zinc-binding

    2. NM_001027486.5 → NP_001022657.1  Putative ATP-dependent DNA helicase Q1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TXJ8
      Conserved Domains (4) summary
      TIGR00614
      Location:76 → 548
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd00079
      Location:280 → 412
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:88 → 258
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:417 → 473
      RecQ_Zn_bind; RecQ zinc-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TXJ8.3

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