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    rcor-1 REST corepressor rcor-1 [ Caenorhabditis elegans ]

    Gene ID: 171592, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rcor-1
    Official Full Name
    REST corepressor rcor-1
    Primary source
    WormBase:WBGene00022278
    Locus tag
    CELE_Y74C9A.4
    See related
    AllianceGenome:WB:WBGene00022278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human RCOR1 (REST corepressor 1); RCOR2 (REST corepressor 2); and RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rcor-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (17484..26781, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Alpha N-terminal protein methyltransferase 1 Neighboring gene Peptide P4 Neighboring gene pseudo Neighboring gene Sestrin homolog Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans. Kim HM, et al. Genetics, 2018 Jun. PMID 29588287, Free PMC Article
    2. H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans. Vandamme J, et al. Nucleic Acids Res, 2015 Nov 16. PMID 26476455, Free PMC Article
    3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    REST corepressor rcor-1
    NP_001293207.1
    • Confirmed by transcript evidence
    NP_001293208.1
    • Confirmed by transcript evidence
    NP_490662.1
    • Partially confirmed by transcript evidence
    NP_490663.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      17484..26781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058262.7 → NP_490663.1  REST corepressor rcor-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZI1
      Conserved Domains (2) summary
      pfam00249
      Location:499 → 538
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam00320
      Location:272 → 305
      GATA; GATA zinc finger

    2. NM_058261.5 → NP_490662.1  REST corepressor rcor-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KZI1, Q95Y41, V6CK76, V6CLK9
      Conserved Domains (2) summary
      pfam00249
      Location:502 → 541
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam00320
      Location:275 → 308
      GATA; GATA zinc finger

    3. NM_001306278.3 → NP_001293207.1  REST corepressor rcor-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CK76
      Conserved Domains (2) summary
      pfam00249
      Location:471 → 510
      Myb_DNA-binding; Myb-like DNA-binding domain
      cl21498
      Location:164 → 208
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    4. NM_001306279.3 → NP_001293208.1  REST corepressor rcor-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLK9
      Conserved Domains (1) summary
      pfam00249
      Location:212 → 251
      Myb_DNA-binding; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95Y41.1

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