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    bbs-1 BBSome complex member BBS1 [ Caenorhabditis elegans ]

    Gene ID: 260219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bbs-1
    Official Full Name
    BBSome complex member BBS1
    Primary source
    WormBase:WBGene00000241
    Locus tag
    CELE_Y105E8A.5
    See related
    AllianceGenome:WB:WBGene00000241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable patched binding activity and smoothened binding activity. Involved in non-motile cilium assembly. Acts upstream of or within intraciliary retrograde transport and protein localization to cilium. Located in axoneme; ciliary basal body; and neuron projection. Is expressed in intestine and nervous system. Used to study obesity. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 1. Orthologous to human BBS1 (Bardet-Biedl syndrome 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bbs-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (14371138..14376086, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Proton-coupled zinc antiporter SLC30A5 Neighboring gene pre-microRNA mir-8187 Neighboring gene Enoyl-CoA hydratase, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ig-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Physiological and molecular control of lipid accumulation in Caenorhabditis elegans]. Xu XM, et al. Sheng Li Ke Xue Jin Zhan, 2009 Apr. PMID 19558141
    2. Polygenic control of Caenorhabditis elegans fat storage. Mak HY, et al. Nat Genet, 2006 Mar. PMID 16462744
    3. Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Blacque OE, et al. Genes Dev, 2004 Jul 1. PMID 15231740, Free PMC Article
    4. Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Piasecki BP, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615967, Free PMC Article
    5. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Ansley SJ, et al. Nature, 2003 Oct 9. PMID 14520415

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables patched binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables smoothened binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intraciliary retrograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of BBSome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BBSome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BBSome complex member BBS1
    NP_740933.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14371138..14376086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170937.3 → NP_740933.1  BBSome complex member BBS1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740933.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NEZ7
      Conserved Domains (1) summary
      pfam14779
      Location:12 → 261
      BBS1; Ciliary BBSome complex subunit 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NEZ7.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.