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    pacs-1 Phosphofurin acidic cluster sorting protein 2 [ Caenorhabditis elegans ]

    Gene ID: 179304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pacs-1
    Official Full Name
    Phosphofurin acidic cluster sorting protein 2
    Primary source
    WormBase:WBGene00044077
    Locus tag
    CELE_T18H9.7
    See related
    AllianceGenome:WB:WBGene00044077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein localization to plasma membrane. Is expressed in several structures, including excretory cell; intestine; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in Schuurs-Hoeijmakers Syndrome and developmental and epileptic encephalopathy 66. Orthologous to human PACS1 (phosphofurin acidic cluster sorting protein 1) and PACS2 (phosphofurin acidic cluster sorting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pacs-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (9213754..9217258, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Peptidase A1 domain-containing protein Neighboring gene Innexin;Innexin-10 Neighboring gene MeDiaTor Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Shen Q, et al. Mol Biol Cell, 2014 Jan. PMID 24196833, Free PMC Article
    2. Stable-isotope labeling with amino acids in nematodes. Larance M, et al. Nat Methods, 2011 Aug 28. PMID 21874007, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphofurin acidic cluster sorting protein 2
    NP_505387.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9213754..9217258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072986.9 → NP_505387.1  Phosphofurin acidic cluster sorting protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QA3
      Conserved Domains (1) summary
      pfam10254
      Location:395 → 799
      Pacs-1; PACS-1 cytosolic sorting protein
    Nucleotide Protein
    Heading Accession and Version

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