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    mut-15 MUTator [ Caenorhabditis elegans ]

    Gene ID: 180000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mut-15
    Official Full Name
    MUTator
    Primary source
    WormBase:WBGene00011323
    Locus tag
    CELE_T01C3.8
    See related
    AllianceGenome:WB:WBGene00011323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in mutator focus. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mut-15 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (15002543..15005067)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Spore coat protein;Transmembrane protein Neighboring gene Small ribosomal subunit protein uS9 Neighboring gene rRNA 2'-O-methyltransferase fibrillarin Neighboring gene Protein hrde-2 Neighboring gene Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein Neighboring gene Oxysterol binding protein;Oxysterol-binding protein Neighboring gene ncRNA Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Phillips CM, et al. Genes Dev, 2012 Jul 1. PMID 22713602, Free PMC Article
    2. Disruption of the mutator complex triggers a low penetrance larval arrest phenotype. Rogers AK, et al. MicroPubl Biol, 2020. PMID 32542232, Free PMC Article
    3. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Tsai HY, et al. Cell, 2015 Jan 29. PMID 25635455, Free PMC Article
    4. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. Uebel CJ, et al. PLoS Genet, 2018 Jul. PMID 30036386, Free PMC Article
    5. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Phillips CM, et al. Curr Biol, 2014 Apr 14. PMID 24684932, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in mutator focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MUTator
    NP_001256638.1
    • Product from WormBase gene class mut;
      Confirmed by transcript evidence
    NP_001256639.1
    • Product from WormBase gene class mut;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15002543..15005067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269709.2 → NP_001256638.1  MUTator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22061

    2. NM_001269710.3 → NP_001256639.1  MUTator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6U1
    Nucleotide Protein
    Heading Accession and Version

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