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    mdt-28 Coiled-coil domain-containing protein mdt-28 [ Caenorhabditis elegans ]

    Gene ID: 180048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdt-28
    Official Full Name
    Coiled-coil domain-containing protein mdt-28
    Primary source
    WormBase:WBGene00009223
    Locus tag
    CELE_F28F8.5
    See related
    AllianceGenome:WB:WBGene00009223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including gonad; hypodermis; and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mdt-28 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (15574098..15575405, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Ataxin-3 homolog Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Valproic Acid Decreases the Nuclear Localization of MDT-28, the Nematode Orthologue of MED28. Kostrouchová M, et al. Folia Biol (Praha), 2018. PMID 29871732
    2. The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development. Kostrouchová M, et al. PeerJ, 2017. PMID 28603670, Free PMC Article
    3. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
    4. Dietary S. maltophilia induces supersized lipid droplets by enhancing lipogenesis and ER-LD contacts in C. elegans. Xie K, et al. Gut Microbes, 2022 Jan-Dec. PMID 35112996, Free PMC Article
    5. MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans. Xie K, et al. Sci Rep, 2019 Oct 17. PMID 31624276, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans.
      Title: MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans.
    2. The results provide evidence for MDT-28 engagement in the Mediator Head module and support the possibility of physical (direct or indirect) interaction of MDT-28 with additional proteins.
      Title: Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Coiled-coil domain-containing protein mdt-28
    NP_001256673.1
    • Confirmed by transcript evidence
    NP_001380113.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15574098..15575405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269744.2 → NP_001256673.1  Coiled-coil domain-containing protein mdt-28 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9G301

    2. NM_001392672.1 → NP_001380113.1  Coiled-coil domain-containing protein mdt-28 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9G301, O18692
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9G301.1

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