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    vps-60 Charged multivesicular body protein 5 [ Caenorhabditis elegans ]

    Gene ID: 179242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-60
    Official Full Name
    Charged multivesicular body protein 5
    Primary source
    WormBase:WBGene00018290
    Locus tag
    CELE_F41E6.9
    See related
    AllianceGenome:WB:WBGene00018290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Predicted to be active in multivesicular body. Orthologous to human CHMP5 (charged multivesicular body protein 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-60 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (8605088..8606128, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Sushi domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene FMN hydroxy acid dehydrogenase domain-containing protein Neighboring gene Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein Neighboring gene Fungus-Induced Protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
    2. The ESCRT machinery directs quality control over inner nuclear membrane architecture. Shankar R, et al. Cell Rep, 2022 Jan 18. PMID 35045304, Free PMC Article
    3. Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness. Geens E, et al. Life Sci Alliance, 2023 Jun. PMID 37059473, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Charged multivesicular body protein 5
    NP_505219.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8605088..8606128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072818.6 → NP_505219.1  Charged multivesicular body protein 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505219.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16458
      Conserved Domains (1) summary
      cl21588
      Location:1 → 191
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version

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