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    kcc-1 K+/Cl-Cotransporter;Solute carrier family 12 member 6 [ Caenorhabditis elegans ]

    Gene ID: 177495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kcc-1
    Official Full Name
    K+/Cl-Cotransporter;Solute carrier family 12 member 6
    Primary source
    WormBase:WBGene00006504
    Locus tag
    CELE_R13A1.2
    See related
    AllianceGenome:WB:WBGene00006504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables potassium:chloride symporter activity. Involved in chloride transmembrane transport and potassium ion transmembrane transport. Predicted to be located in membrane and synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including hermaphrodite distal tip cell; pharyngeal muscle cell; tail neurons; ventral nerve cord; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kcc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (7206269..7218002)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Degenerin unc-8 Neighboring gene ncRNA Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Globin domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter. Zimanyi CM, et al. Structure, 2020 Sep 1. PMID 32679039, Free PMC Article
    2. Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans. Holtzman EJ, et al. Am J Physiol, 1998 Oct. PMID 9755127
    3. The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. Tanis JE, et al. J Neurosci, 2009 Aug 12. PMID 19675228, Free PMC Article
    4. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article
    5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.
      Title: Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    K+/Cl-Cotransporter;Solute carrier family 12 member 6
    NP_001293846.1
    • Confirmed by transcript evidence
    NP_001293847.1
    • Confirmed by transcript evidence
    NP_001293848.1
    • Confirmed by transcript evidence
    NP_001294072.1
    • Confirmed by transcript evidence
    NP_001368174.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7206269..7218002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306917.3 → NP_001293846.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293846.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FWN4
      Conserved Domains (2) summary
      TIGR00930
      Location:166 → 1153
      2a30; K-Cl cotransporter
      pfam03522
      Location:776 → 1153
      SLC12; Solute carrier family 12

    2. NM_001306918.3 → NP_001293847.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293847.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F510
      Conserved Domains (2) summary
      TIGR00930
      Location:108 → 1095
      2a30; K-Cl cotransporter
      pfam03522
      Location:718 → 1095
      SLC12; Solute carrier family 12

    3. NM_001306919.3 → NP_001293848.1  Solute carrier family 12 member 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FCX2
      Conserved Domains (2) summary
      TIGR00930
      Location:76 → 1063
      2a30; K-Cl cotransporter
      pfam03522
      Location:686 → 1063
      SLC12; Solute carrier family 12

    4. NM_001307143.2 → NP_001294072.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NV09
      Conserved Domains (2) summary
      TIGR00930
      Location:121 → 1108
      2a30; K-Cl cotransporter
      pfam03522
      Location:731 → 1108
      SLC12; Solute carrier family 12

    5. NM_001380315.1 → NP_001368174.1  Solute carrier family 12 member 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NVB5
      Conserved Domains (1) summary
      TIGR00930
      Location:45 → 1032
      2a30; K-Cl cotransporter
    Nucleotide Protein
    Heading Accession and Version

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