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    emb-4 AAA_12 domain-containing protein;DNA2/NAM7 helicase-like C-terminal domain-containing protein;Intron-binding protein aquarius [ Caenorhabditis elegans ]

    Gene ID: 180232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    emb-4
    Official Full Name
    AAA_12 domain-containing protein;DNA2/NAM7 helicase-like C-terminal domain-containing protein;Intron-binding protein aquarius
    Primary source
    WormBase:WBGene00001258
    Locus tag
    CELE_Y80D3A.2
    See related
    AllianceGenome:WB:WBGene00001258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Is expressed in embryonic cell and germ line. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See emb-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    19
    Sequence:
    Chromosome: V; NC_003283.11 (18860285..18894974, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-65 Neighboring gene Nuclear Hormone Receptor family Neighboring gene tryptophan--tRNA ligase Neighboring gene Homeobox protein ceh-51 Neighboring gene Nuclear Hormone Receptor family Neighboring gene Neuropeptide CCHamide-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Conserved Intron Binding Protein EMB-4 Plays Differential Roles in Germline Small RNA Pathways of C. elegans. Tyc KM, et al. Dev Cell, 2017 Aug 7. PMID 28787592
    2. emb-4 is a conserved gene required for efficient germline-specific chromatin remodeling during Caenorhabditis elegans embryogenesis. Checchi PM, et al. Genetics, 2006 Dec. PMID 17028322, Free PMC Article
    3. EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Katic I, et al. Genetics, 2006 Dec. PMID 17030954, Free PMC Article
    4. Cell lineages and developmental defects of temperature-sensitive embryonic arrest mutants in Caenorhabditis elegans. Schierenberg E, et al. Dev Biol, 1980 Apr. PMID 7380087
    5. Genetics and mode of expression of temperature-sensitive mutations arresting embryonic development in Caenorhabditis elegans. Miwa J, et al. Dev Biol, 1980 Apr. PMID 7380089

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EMB-4 interacts with the CSR-1 and HRDE-1. Loss of EMB-4 leads to perturbations in germline small RNA and mRNA transcriptomes.
      Title: The Conserved Intron Binding Protein EMB-4 Plays Differential Roles in Germline Small RNA Pathways of C. elegans.
    2. EMB-4 physically interacts with the helicase HRDE-1. EMB-4 is required for heritable silencing of genes and transposable elements.
      Title: The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AAA_12 domain-containing protein;DNA2/NAM7 helicase-like C-terminal domain-containing protein;Intron-binding protein aquarius
    NP_001256831.1
    • Confirmed by transcript evidence
    NP_001256832.1
    • Confirmed by transcript evidence
    NP_001256833.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18860285..18894974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269902.2 → NP_001256831.1  Intron-binding protein aquarius [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1Q7
      Conserved Domains (5) summary
      COG1112
      Location:1012 → 1327
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam13086
      Location:805 → 1106
      AAA_11; AAA domain
      pfam13245
      Location:811 → 884
      AAA_19; Part of AAA domain
      pfam16399
      Location:16 → 806
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:1117 → 1310
      UvrD_C_2; UvrD-like helicase C-terminal domain

    2. NM_001269903.3 → NP_001256832.1  DNA2/NAM7 helicase-like C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D8FRP8
      Conserved Domains (1) summary
      cd18808
      Location:5 → 100
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

    3. NM_001269904.3 → NP_001256833.1  AAA_12 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D8FRP9
    Nucleotide Protein
    Heading Accession and Version

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