eif-3.K Eukaryotic translation initiation factor 3 subunit K [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eif-3.K
Official Full Name: Eukaryotic translation initiation factor 3 subunit K
Primary source: WormBase:WBGene00001233
Locus tag: CELE_T16G1.11
See related: AllianceGenome:WB:WBGene00001233
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity and ribosome binding activity. Predicted to contribute to translation initiation factor activity. Involved in positive regulation of apoptotic process. Located in cytoplasm. Is expressed in several structures, including germ line. Orthologous to human EIF3K (eukaryotic translation initiation factor 3 subunit K). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eif-3.K in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (12954002..12955229)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pivotal functional role for conserved eIF3k and eIF3l accessory subunits of eIF3 in the regulation of cellular and organismal responses to ER stress and aging.
Title: Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans.
C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase.
Title: C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T16G1.11 (e-PCR)
- UniSTS:318493

T16G1.10 (e-PCR)
- UniSTS:317077

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Eukaryotic translation initiation factor 3 subunit K

NP_506241.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12954002..12955229

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073840.8 → NP_506241.1 Eukaryotic translation initiation factor 3 subunit K [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506241.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0VI97, Q9XUP3

Conserved Domains (2) summary

pfam15867
Location:1 → 63

Dynein_attach_N; Dynein attachment factor N-terminus

cl24019
Location:64 → 208

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family