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    gtl-1 TRPM SLOG domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gtl-1
    Official Full Name
    TRPM SLOG domain-containing protein
    Primary source
    WormBase:WBGene00001795
    Locus tag
    CELE_C05C12.3
    See related
    AllianceGenome:WB:WBGene00001795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; congenital stationary night blindness; and congenital stationary night blindness 1C. Orthologous to human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gtl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    32
    Sequence:
    Chromosome: IV; NC_003282.8 (11248884..11259535, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Phosphoprotein Neighboring gene KH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception. Cohen E, et al. Front Pharmacol, 2019. PMID 32009965, Free PMC Article
    2. TRPM channel function in Caenorhabditis elegans. Baylis HA, et al. Biochem Soc Trans, 2007 Feb. PMID 17233618
    3. Highly Ca2+-selective TRPM channels regulate IP3-dependent oscillatory Ca2+ signaling in the C. elegans intestine. Xing J, et al. J Gen Physiol, 2008 Mar. PMID 18299395, Free PMC Article
    4. Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors. Husson SJ, et al. Curr Biol, 2012 May 8. PMID 22483941, Free PMC Article
    5. Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine. Teramoto T, et al. Cell Metab, 2005 May. PMID 16054081, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1
      Title: Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
    2. PIP(2)-dependent regulation of GON-2/GTL-1 may provide a mechanism to coordinate plasma membrane Ca(2+) influx with PLCgamma and IP(3) receptor activity as well as intracellular Ca(2+) store depletion.
      Title: Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.
    3. The GTL-1 mainly contributes to appropriate Mg(2+) responsiveness of the outwardly rectifying current.
      Title: Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defecation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TRPM SLOG domain-containing protein
    NP_502111.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11248884..11259535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069710.6 → NP_502111.3  TRPM SLOG domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502111.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM4, Q8IG05
      Conserved Domains (2) summary
      pfam00520
      Location:1081 → 1328
      Ion_trans; Ion transport protein
      pfam18139
      Location:208 → 471
      LSDAT_euk; SLOG in TRPM
    Nucleotide Protein
    Heading Accession and Version

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