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    metl-6 tRNA N(3)-methylcytidine methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 175507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    metl-6
    Official Full Name
    tRNA N(3)-methylcytidine methyltransferase
    Primary source
    WormBase:WBGene00014205
    Locus tag
    CELE_ZK1058.5
    See related
    AllianceGenome:WB:WBGene00014205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in RNA methylation. Orthologous to human METTL6 (methyltransferase 6, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See metl-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (3920628..3921711, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Integrin beta pat-3 Neighboring gene PAT complex subunit CCDC47 Neighboring gene putative galactose-1-phosphate uridylyltransferase Neighboring gene CN hydrolase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene mRNA 5'-triphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Liberman N, et al. Sci Adv, 2020 Apr. PMID 32494643, Free PMC Article
    2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N(3)-methylcytidine methyltransferase
    NP_497790.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3920628..3921711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065389.6 → NP_497790.2  tRNA N(3)-methylcytidine methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497790.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23383
      Conserved Domains (2) summary
      COG0500
      Location:44 → 269
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version

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