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    snx-6 PX domain-containing protein;Sorting nexin/Vps5-like C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx-6
    Official Full Name
    PX domain-containing protein;Sorting nexin/Vps5-like C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00013354
    Locus tag
    CELE_Y59A8B.22
    See related
    AllianceGenome:WB:WBGene00013354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol binding activity. Involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance. Located in early phagosome. Orthologous to human SNX32 (sorting nexin 32); SNX5 (sorting nexin 5); and SNX6 (sorting nexin 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snx-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (17968263..17980082, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Germinal center kinase 3 Neighboring gene MFS domain-containing protein Neighboring gene Protein lon-8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Lu N, et al. Mol Biol Cell, 2011 Feb 1. PMID 21148288, Free PMC Article
    2. SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking. Tian Y, et al. PLoS Genet, 2021 Jun. PMID 34081703, Free PMC Article
    3. Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry. Beer KB, et al. Proc Natl Acad Sci U S A, 2018 Feb 6. PMID 29367422, Free PMC Article
    4. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Chen D, et al. Science, 2010 Mar 5. PMID 20133524
    5. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Harterink M, et al. Nat Cell Biol, 2011 Jul 3. PMID 21725319, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagolysosome assembly involved in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagosome maturation involved in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagosome-lysosome fusion involved in apoptotic cell clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagosome-lysosome fusion involved in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early phagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PX domain-containing protein;Sorting nexin/Vps5-like C-terminal domain-containing protein
    NP_001256763.1
    • Confirmed by transcript evidence
    NP_001256764.1
    • Confirmed by transcript evidence
    NP_001256765.1
    • Confirmed by transcript evidence
    NP_001256766.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17968263..17980082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269834.2 → NP_001256763.1  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTP5
      Conserved Domains (2) summary
      cd06892
      Location:102 → 241
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cd07621
      Location:257 → 475
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6

    2. NM_001269835.3 → NP_001256764.1  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTP6
      Conserved Domains (2) summary
      cd06892
      Location:5 → 144
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cd07621
      Location:160 → 378
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6

    3. NM_001269836.3 → NP_001256765.1  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTP7
      Conserved Domains (2) summary
      cd07621
      Location:127 → 345
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:2 → 111
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    4. NM_001269837.3 → NP_001256766.1  Sorting nexin/Vps5-like C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256766.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTP8
      Conserved Domains (1) summary
      cl12013
      Location:1 → 130
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version

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