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    M01E11.1 Protein-S-isoprenylcysteine O-methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 187374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    M01E11.1
    Official Full Name
    Protein-S-isoprenylcysteine O-methyltransferase
    Primary source
    WormBase:WBGene00019710
    Locus tag
    CELE_M01E11.1
    See related
    AllianceGenome:WB:WBGene00019710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Predicted to be involved in C-terminal protein methylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See M01E11.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (5582096..5583471)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Kinesin motor domain-containing protein Neighboring gene Beta-catenin-like protein 1 N-terminal domain-containing protein Neighboring gene Tensin homolog Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C-terminal protein methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein-S-isoprenylcysteine O-methyltransferase
    NP_491635.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5582096..5583471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059234.5 → NP_491635.1  Protein-S-isoprenylcysteine O-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491635.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91402
      Conserved Domains (1) summary
      pfam04140
      Location:177 → 267
      ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family
    Nucleotide Protein
    Heading Accession and Version

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