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    jip-1 JNK-interacting protein 1;PID domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jip-1
    Official Full Name
    JNK-interacting protein 1;PID domain-containing protein
    Primary source
    WormBase:WBGene00002176
    Locus tag
    CELE_F56D12.4
    See related
    AllianceGenome:WB:WBGene00002176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See jip-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    19
    Sequence:
    Chromosome: II; NC_003280.10 (1326989..1350132)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hyaluronan/mRNA-binding protein domain-containing protein Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WSC domain-containing protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Jaeschke A, et al. Genes Dev, 2004 Aug 15. PMID 15314024, Free PMC Article
    2. The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex. van den Berg MC, et al. J Biol Chem, 2013 Jul 26. PMID 23770673, Free PMC Article
    3. Roles of MAP kinase cascades in Caenorhabditis elegans. Sakaguchi A, et al. J Biochem, 2004 Jul. PMID 15269234
    4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identify JIP1 as a novel molecular target for therapeutic intervention in the development of obesity
      Title: An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    JNK-interacting protein 1;PID domain-containing protein
    NP_001033331.1
    • Confirmed by transcript evidence
    NP_001033332.1
    • Confirmed by transcript evidence
    NP_001364548.1
    • Confirmed by transcript evidence
    NP_001364697.1
    • Confirmed by transcript evidence
    NP_001407480.1
    • Partially confirmed by transcript evidence
    NP_001407481.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1326989..1350132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377692.2 → NP_001364548.1  PID domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MN04
      Conserved Domains (2) summary
      cd11801
      Location:772 → 826
      SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
      cd01212
      Location:850 → 996
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    2. NM_001377691.2 → NP_001364697.1  PID domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4RZC8
      Conserved Domains (2) summary
      cd11801
      Location:777 → 831
      SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
      cd01212
      Location:855 → 1001
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    3. NM_001038242.6 → NP_001033331.1  JNK-interacting protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4RZC9
      Conserved Domains (2) summary
      cd11801
      Location:298 → 352
      SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
      cd01212
      Location:376 → 522
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    4. NM_001420585.1 → NP_001407481.1  JNK-interacting protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MQ27

    5. NM_001420586.1 → NP_001407480.1  JNK-interacting protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MNX6

    6. NM_001038243.6 → NP_001033332.1  JNK-interacting protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16643
      Conserved Domains (2) summary
      cd11801
      Location:144 → 198
      SH3_JIP1_like; Src homology 3 domain of JNK-interacting proteins 1 and 2, and similar domains
      cd01212
      Location:222 → 368
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein
    Heading Accession and Version

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