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    lgc-55 Ligand-Gated ion Channel [ Caenorhabditis elegans ]

    Gene ID: 180312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgc-55
    Official Full Name
    Ligand-Gated ion Channel
    Primary source
    WormBase:WBGene00013746
    Locus tag
    CELE_Y113G7A.5
    See related
    AllianceGenome:WB:WBGene00013746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables chloride channel activity. Involved in chloride transport and mechanosensory behavior. Located in neuronal cell body and postsynaptic density. Is expressed in several structures, including GLR; egg-laying apparatus; head muscle; nerve ring; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgc-55 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (20023046..20036657)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene Ashwin Neighboring gene pseudo Neighboring gene CX domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyraminergic corollary discharge filters reafferent perception in a chemosensory neuron. Riedl J, et al. Curr Biol, 2022 Jul 25. PMID 35690069
    2. Amphetamine activates an amine-gated chloride channel to generate behavioral effects in Caenorhabditis elegans. Safratowich BD, et al. J Biol Chem, 2013 Jul 26. PMID 23775081, Free PMC Article
    3. Amphetamine activates/potentiates a ligand-gated ion channel. Carvelli L. Channels (Austin), 2014. PMID 25478621, Free PMC Article
    4. Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition. Collins KM, et al. Elife, 2016 Nov 16. PMID 27849154, Free PMC Article
    5. Nematodes win an 'evolutionary arms race' with fungi. Rosania K. Lab Anim (NY), 2011 Aug 19. PMID 21857635

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the behavioral effects of amphetamine is mediated through activation of the amine-gated chloride channel, LGC-55.
      Title: Amphetamine activates an amine-gated chloride channel to generate behavioral effects in Caenorhabditis elegans.
    2. study identified 3 ligand-gated chloride channels that are receptors for biogenic amines: LGC-53 is a high-affinity dopamine receptor, LGC-55 is a high-affinity tyramine receptor & LGC-40 is a low-affinity serotonin receptor
      Title: Ligand-gated chloride channels are receptors for biogenic amines in C. elegans.
    3. lgc-55 coordinates distinct motor programs of a Caenorhabditis elegans escape response.
      Title: A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ligand-Gated ion Channel
    NP_507870.2
    • Product from WormBase gene class lgc;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20023046..20036657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075469.7 → NP_507870.2  Ligand-Gated ion Channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507870.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEC1
      Conserved Domains (3) summary
      TIGR00860
      Location:90 → 532
      LIC; Cation transporter family protein
      pfam02931
      Location:88 → 295
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:304 → 391
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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