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    sand-1 Vacuolar fusion protein MON1 homolog [ Caenorhabditis elegans ]

    Gene ID: 177318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sand-1
    Official Full Name
    Vacuolar fusion protein MON1 homolog
    Primary source
    WormBase:WBGene00018321
    Locus tag
    CELE_F41H10.11
    See related
    AllianceGenome:WB:WBGene00018321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including early endosome to late endosome transport; phagosome maturation involved in apoptotic cell clearance; and positive regulation of early endosome to late endosome transport. Located in early endosome and membrane. Orthologous to several human genes including MON1B (MON1 homolog B, secretory trafficking associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sand-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (5366867..5368865)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GRIP domain-containing protein Neighboring gene PHD-type domain-containing protein;RNA-directed RNA polymerase Neighboring gene Long chain fatty acid elongase 5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SAND, a new protein family: from nucleic acid to protein structure and function prediction. Cottage A, et al. Comp Funct Genomics, 2001. PMID 18628914, Free PMC Article
    2. Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis. Morris C, et al. PLoS Genet, 2018 Nov. PMID 30419011, Free PMC Article
    3. Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans. Solinger JA, et al. Mol Biol Cell, 2014 Dec 1. PMID 25273556, Free PMC Article
    4. Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell. Wang Y, et al. Elife, 2023 Mar 2. PMID 36861960, Free PMC Article
    5. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Kinchen JM, et al. Nature, 2010 Apr 1. PMID 20305638, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCZ-1 and the HOPS complex are essential for the biogenesis of gut granules, cell type-specific, lysosome-related organelles that coexist with conventional lysosomes in Caenorhabditis elegans intestinal cells, independent of RAB-7 and SAND-1.
      Title: Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.
    2. data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses
      Title: Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.
    3. SAND-1 is essential for RAB-7 function at the transition from early to late endosomes, but not for RAB-7 function at lysosomes.
      Title: Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in early endosome to late endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagosome maturation involved in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of early endosome to late endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of early endosome to late endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar fusion protein MON1 homolog
    NP_500791.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5366867..5368865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068390.9 → NP_500791.2  Vacuolar fusion protein MON1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500791.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BI89
      Conserved Domains (1) summary
      pfam03164
      Location:50 → 458
      Mon1; Trafficking protein Mon1
    Nucleotide Protein
    Heading Accession and Version

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