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    ubr-1 E3 ubiquitin-protein ligase ubr-1 [ Caenorhabditis elegans ]

    Gene ID: 171953, updated on 9-Dec-2024

    Summary

    Official Symbol
    ubr-1
    Official Full Name
    E3 ubiquitin-protein ligase ubr-1
    Primary source
    WormBase:WBGene00016326
    Locus tag
    CELE_C32E8.11
    See related
    AllianceGenome:WB:WBGene00016326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin conjugating enzyme binding activity. Involved in negative regulation of glutamate metabolic process and regulation of backward locomotion. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in body wall musculature; lateral ganglion; neurons; pharynx; and seam cell. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome and cardiovascular system disease. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1) and UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ubr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (3807456..3816809, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ethylmalonyl-CoA decarboxylase Neighboring gene RING-type domain-containing protein Neighboring gene Phosphatidylinositol-binding clathrin assembly protein unc-11 Neighboring gene Nsp1_C domain-containing protein Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ubr-1
    NP_491231.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3807456..3816809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058830.6NP_491231.2  E3 ubiquitin-protein ligase ubr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491231.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91133
      Conserved Domains (2) summary
      smart00396
      Location:93163
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      pfam02617
      Location:217305
      ClpS; ATP-dependent Clp protease adaptor protein ClpS