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    nhx-3 putative Na(+)/H(+) antiporter nhx-3 [ Caenorhabditis elegans ]

    Gene ID: 183811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhx-3
    Official Full Name
    putative Na(+)/H(+) antiporter nhx-3
    Primary source
    WormBase:WBGene00003731
    Locus tag
    CELE_C54F6.13
    See related
    AllianceGenome:WB:WBGene00003731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in endomembrane system and membrane. Predicted to be active in plasma membrane. Is expressed in epithelial cell; hypodermis; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8 and end stage renal disease. Orthologous to human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhx-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (7540890..7544838, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DUF19 domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene SWIM-type domain-containing protein Neighboring gene Ferritin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene knockout of NHX-3 in the soil nematode Caenorhabditis elegans leads to broad-spectrum compensatory regulation of Na(+)/H(+) exchangers, antiporters, and the V-type H(+)-ATPase. Adlimoghaddam A, et al. Comp Biochem Physiol A Mol Integr Physiol, 2023 Aug. PMID 37263376
    2. Ammonia excretion in Caenorhabditis elegans: Physiological and molecular characterization of the rhr-2 knock-out mutant. Adlimoghaddam A, et al. Comp Biochem Physiol A Mol Integr Physiol, 2016 May. PMID 26872996
    3. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Golden TR, et al. Aging Cell, 2008 Dec. PMID 18778409, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene knockout of NHX-3 in the soil nematode Caenorhabditis elegans leads to broad-spectrum compensatory regulation of Na[+]/H[+] exchangers, antiporters, and the V-type H[+]-ATPase.
      Title: Gene knockout of NHX-3 in the soil nematode Caenorhabditis elegans leads to broad-spectrum compensatory regulation of Na(+)/H(+) exchangers, antiporters, and the V-type H(+)-ATPase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative Na(+)/H(+) antiporter nhx-3
    NP_001023735.1
    • Confirmed by transcript evidence
    NP_001023736.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7540890..7544838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028564.6 → NP_001023735.1  putative Na(+)/H(+) antiporter nhx-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023735.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16452, Q71VC7, Q8T5S0
      Conserved Domains (1) summary
      pfam00999
      Location:44 → 444
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. NM_001028565.4 → NP_001023736.1  putative Na(+)/H(+) antiporter nhx-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023736.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16452
      Conserved Domains (1) summary
      pfam00999
      Location:25 → 425
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16452.2

    Gene LinkOut

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