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    cdkr-3 CDK5RAP3 protein homolog [ Caenorhabditis elegans ]

    Gene ID: 180327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdkr-3
    Official Full Name
    CDK5RAP3 protein homolog
    Primary source
    WormBase:WBGene00013765
    Locus tag
    CELE_Y113G7B.16
    See related
    AllianceGenome:WB:WBGene00013765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in IRE1-mediated unfolded protein response. Predicted to be active in endomembrane system. Is expressed in intestine; neurons; pharynx; and spermatheca. Used to study early infantile epileptic encephalopathy. Orthologous to human CDK5RAP3 (CDK5 regulatory subunit associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdkr-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (20270107..20275695)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 17 Neighboring gene Protein arginine N-methyltransferase 1 Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans. Hertel P, et al. J Biol Chem, 2013 Apr 12. PMID 23449979, Free PMC Article
    2. Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy. Colin E, et al. Am J Hum Genet, 2016 Sep 1. PMID 27545681, Free PMC Article
    3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    4. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CDK5RAP3 protein homolog
    NP_001370069.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20270107..20275695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383506.2 → NP_001370069.1  CDK5RAP3 protein homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U2Y2
      Conserved Domains (1) summary
      pfam05600
      Location:3 → 480
      DUF773; Protein of unknown function (DUF773)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2Y2.1

    Gene LinkOut

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