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    spp-11 Leguminosin group485 secreted peptide;Saposin B-type domain-containing protein;Saposin-like protein 11 [ Caenorhabditis elegans ]

    Gene ID: 174063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spp-11
    Official Full Name
    Leguminosin group485 secreted peptide;Saposin B-type domain-containing protein;Saposin-like protein 11
    Primary source
    WormBase:WBGene00004996
    Locus tag
    CELE_T25D10.3
    See related
    AllianceGenome:WB:WBGene00004996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spp-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (6405388..6407379, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas HR, et al. Mol Immunol, 2004 Jul. PMID 15183927
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    Leguminosin group485 secreted peptide;Saposin B-type domain-containing protein;Saposin-like protein 11
    NP_001352251.1
    • Confirmed by transcript evidence
    NP_001355419.1
    • Confirmed by transcript evidence
    NP_001355420.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6405388..6407379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001368591.4 → NP_001355419.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10018
      UniProtKB/TrEMBL
      A0A3B1E8S4
      Conserved Domains (2) summary
      PRK15370
      Location:74 → 291
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00741
      Location:298 → 383
      SapB; Saposin (B) Domains

    2. NM_001365320.2 → NP_001352251.1  Saposin-like protein 11 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00741
      Location:160 → 245
      SapB; Saposin (B) Domains

    3. NM_001368592.3 → NP_001355420.1  Leguminosin group485 secreted peptide [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3B1DQA9
    Nucleotide Protein
    Heading Accession and Version

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