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    gcy-23 Receptor-type guanylate cyclase gcy-23 [ Caenorhabditis elegans ]

    Gene ID: 191652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-23
    Official Full Name
    Receptor-type guanylate cyclase gcy-23
    Primary source
    WormBase:WBGene00001548
    Locus tag
    CELE_T26C12.4
    See related
    AllianceGenome:WB:WBGene00001548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in neuron projection terminus. Is expressed in AFDL and AFDR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-23 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (3282885..3289337, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein Upregulated in Glial Subsets Neighboring gene Peptidase M24 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling. Wasserman SM, et al. Curr Biol, 2011 Mar 8. PMID 21315599, Free PMC Article
    2. Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans. Ramot D, et al. Nat Neurosci, 2008 Aug. PMID 18660808, Free PMC Article
    3. Ultrasound Elicits Behavioral Responses through Mechanical Effects on Neurons and Ion Channels in a Simple Nervous System. Kubanek J, et al. J Neurosci, 2018 Mar 21. PMID 29463641, Free PMC Article
    4. cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans. Aoki I, et al. PLoS One, 2022. PMID 36472979, Free PMC Article
    5. GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis. Wang D, et al. J Gen Physiol, 2013 Oct. PMID 24081984, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. three guanylyl cyclases (gcy-8, gcy-18, and gcy-23) function redundantly in the AFD neurons to mediate thermosensation by C. elegans
      Title: Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of temperature stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in detection of temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in thermosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-23
    NP_500309.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3282885..3289337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067908.5 → NP_500309.3  Receptor-type guanylate cyclase gcy-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500309.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEE9
      Conserved Domains (6) summary
      smart00044
      Location:842 → 1035
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd13992
      Location:509 → 806
      PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors
      pfam00211
      Location:869 → 1056
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:38 → 385
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:817 → 863
      HNOBA; Heme NO binding associated
      cl10011
      Location:38 → 407
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEE9.1

    Gene LinkOut

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