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    ced-13 Secreted protein [ Caenorhabditis elegans ]

    Gene ID: 191625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ced-13
    Official Full Name
    Secreted protein
    Primary source
    WormBase:WBGene00000427
    Locus tag
    CELE_R09F10.9
    See related
    AllianceGenome:WB:WBGene00000427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ced-13 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (8299119..8299654, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 27 Neighboring gene ncRNA Neighboring gene Innexin-5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans. Martínez-Fernández C, et al. Dis Model Mech, 2022 Mar 1. PMID 35107130, Free PMC Article
    2. Differential regulation of germline apoptosis in response to meiotic checkpoint activation. Ye AL, et al. Genetics, 2014 Nov. PMID 25217053, Free PMC Article
    3. Caenorhabditis elegans NHR-14/HNF4α regulates DNA damage-induced apoptosis through cooperating with cep-1/p53. Sang L, et al. Cell Commun Signal, 2022 Sep 1. PMID 36050770, Free PMC Article
    4. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Yee C, et al. Cell, 2014 May 8. PMID 24813612, Free PMC Article
    5. Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways. Flowers S, et al. Elife, 2023 Oct 2. PMID 37782016, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables BH domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Secreted protein
    NP_509402.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8299119..8299654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077001.2 → NP_509402.1  Secreted protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509402.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TY06
      Conserved Domains (1) summary
      pfam11430
      Location:53 → 72
      EGL-1; Programmed cell death activator EGL-1
    Nucleotide Protein
    Heading Accession and Version

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