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    agef-1 SEC7 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    agef-1
    Official Full Name
    SEC7 domain-containing protein
    Primary source
    WormBase:WBGene00012386
    Locus tag
    CELE_Y6B3A.1
    See related
    AllianceGenome:WB:WBGene00012386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in protein transport and regulation of ARF protein signal transduction. Is expressed in coelomocyte; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See agef-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    19
    Sequence:
    Chromosome: I; NC_003279.8 (13603906..13626225, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EARP-interacting protein 1 Neighboring gene Lysosomal cobalamin transporter Neighboring gene Ribosome biogenesis protein NSA2 homolog Neighboring gene ncRNA Neighboring gene Septin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different endocytic functions of AGEF-1 in C. elegans coelomocytes. Tang L, et al. Biochim Biophys Acta, 2012 Jul. PMID 22446376
    2. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. Skorobogata O, et al. PLoS Genet, 2014 Oct. PMID 25329472, Free PMC Article
    3. The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans. Ackema KB, et al. PLoS One, 2013. PMID 23840591, Free PMC Article
    4. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Wang C, et al. Neurobiol Dis, 2018 Jan. PMID 28982592
    5. Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. Sato K, et al. Mol Biol Cell, 2006 Jul. PMID 16672374, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 basolateral localization and signaling during C. elegans vulva induction.
      Title: An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SEC7 domain-containing protein
    NP_001021798.2
    • Confirmed by transcript evidence
    NP_001021799.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13603906..13626225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026627.8 → NP_001021798.2  SEC7 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021798.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFH7
      Conserved Domains (1) summary
      PLN03076
      Location:18 → 1476
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

    2. NM_001026628.5 → NP_001021799.1  SEC7 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K783
      Conserved Domains (1) summary
      PLN03076
      Location:18 → 477
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    Nucleotide Protein
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