aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aak-1
Official Full Name: 5'-AMP-activated protein kinase catalytic subunit alpha-1
Primary source: WormBase:WBGene00019801
Locus tag: CELE_PAR2.3
See related: AllianceGenome:WB:WBGene00019801
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of cell population proliferation and nematode pharyngeal pumping. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aak-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (8756990..8761090, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, the authors show that neuronal AMPK is essential for lifespan extension from TORC1 inhibition, and that TORC1 suppression increases lifespan cell non autonomously via distinct mechanisms from global AMPK activation.
Title: Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans.
our results imply that DAF-18/PTEN, through PAR-4/LKB1, can activate AAK-1/AMPK in the absence of apparent energy stress. As all components are conserved, similar signalling cascades may regulate stem cell activities in other organisms and be widely implicated in cancer.
Title: DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PAR2.3 (e-PCR)
- UniSTS:312013

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5'-AMP-activated protein kinase catalytic subunit alpha-1

NP_001380007.1

Confirmed by transcript evidence

NP_741254.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8756990..8761090 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392162.1 → NP_001380007.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

cd14336
Location:121 → 185

UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits

cl17070
Location:219 → 308

AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

cl21453
Location:1 → 105

PKc_like; Protein Kinases, catalytic domain
NM_171216.6 → NP_741254.3 5'-AMP-activated protein kinase catalytic subunit alpha-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741254.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P45894, Q3HKC8, Q3HKC9, Q5VKL2

Conserved Domains (4) summary

cd12122
Location:390 → 479

AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit

smart00220
Location:24 → 276

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14336
Location:292 → 356

UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits

cl21453
Location:21 → 276

PKc_like; Protein Kinases, catalytic domain