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    rab-7 Ras-related protein Rab-7a [ Caenorhabditis elegans ]

    Gene ID: 174834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab-7
    Official Full Name
    Ras-related protein Rab-7a
    Primary source
    WormBase:WBGene00004271
    Locus tag
    CELE_W03C9.3
    See related
    AllianceGenome:WB:WBGene00004271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activity. Involved in several processes, including oocyte growth; phagolysosome assembly involved in apoptotic cell clearance; and positive regulation of early endosome to late endosome transport. Located in late endosome membrane; lysosome; and phagocytic vesicle membrane. Is expressed widely. Used to study obesity. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rab-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (11965523..11966931, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene PTK2 Neighboring gene C3H1-type domain-containing protein Neighboring gene ACB domain-containing protein Neighboring gene BZIP domain-containing protein;Regulator of rDNA transcription 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling. Kvainickas A, et al. J Cell Biol, 2019 Sep 2. PMID 31431476, Free PMC Article
    2. The HEAT repeat protein HPO-27 is a lysosome fission factor. Li L, et al. Nature, 2024 Apr. PMID 38538795
    3. A systems toxicology approach on the mechanism of uptake and toxicity of MWCNT in Caenorhabditis elegans. Eom HJ, et al. Chem Biol Interact, 2015 Sep 5. PMID 26111764
    4. Dynein-mediated trafficking negatively regulates LET-23 EGFR signaling. Skorobogata O, et al. Mol Biol Cell, 2016 Sep 21. PMID 27654944, Free PMC Article
    5. The RBG-1-RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans. Wang Z, et al. J Cell Sci, 2019 Oct 1. PMID 31444285

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCZ-1 and the HOPS complex are essential for the biogenesis of gut granules, cell type-specific, lysosome-related organelles that coexist with conventional lysosomes in Caenorhabditis elegans intestinal cells, independent of RAB-7 and SAND-1.
      Title: Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.
    2. Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.
      Title: Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.
    3. Rab7, by mediating EGFR trafficking and degradation, plays an important role in downregulation of EGFR signaling
      Title: RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans.
    4. Data suggest that TBC-2 functions on RAB-7-positive late endosomes to inactivate RAB-5 during endosome maturation.
      Title: TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans.
    5. Results describe the roles of Rab-5 and -7 in a pathway for phagosome maturation during engulfment of apoptotic cells.
      Title: A pathway for phagosome maturation during engulfment of apoptotic cells.
    6. Results show that either mutation or RNA interference knockdown in rab-7 reduces stored fat in wild type and tub-1 mutants.
      Title: An endocytic pathway as a target of tubby for regulation of fat storage.
    7. SAND-1 is essential for RAB-7 function at the transition from early to late endosomes, but not for RAB-7 function at lysosomes.
      Title: Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oocyte growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phagolysosome assembly involved in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagosome-lysosome fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of early endosome to late endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ras-related protein Rab-7a
    NP_496549.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11965523..11966931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064148.9 → NP_496549.1  Ras-related protein Rab-7a [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7FN66, Q23146
      Conserved Domains (1) summary
      cd01862
      Location:10 → 181
      Rab7; Rab GTPase family 7 (Rab7)
    Nucleotide Protein
    Heading Accession and Version

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