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    rap-3 RAP homolog (vertebrate Rap GTPase family) [ Caenorhabditis elegans ]

    Gene ID: 182417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rap-3
    Official Full Name
    RAP homolog (vertebrate Rap GTPase family)
    Primary source
    WormBase:WBGene00004309
    Locus tag
    CELE_C08F8.7
    See related
    AllianceGenome:WB:WBGene00004309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Rap protein signal transduction and negative regulation of cell migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rap-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (11177267..11178241)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-67 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein Neighboring gene Peroxisomal membrane protein PEX14 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes. Jayadev R, et al. J Cell Biol, 2019 Sep 2. PMID 31387941, Free PMC Article
    2. Small GTPases. Lundquist EA. WormBook, 2006 Jan 17. PMID 18050472, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RAP homolog (vertebrate Rap GTPase family)
    NP_502095.2
    • Product from WormBase gene class rap;
      Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11177267..11178241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069694.4 → NP_502095.2  RAP homolog (vertebrate Rap GTPase family) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502095.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01312
      Conserved Domains (2) summary
      smart00010
      Location:2 → 166
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd00876
      Location:5 → 158
      Ras; Rat sarcoma (Ras) family of small guanosine triphosphatases (GTPases)
    Nucleotide Protein
    Heading Accession and Version

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