F40F8.1 UMP-CMP kinase;UMP-CMP kinase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F40F8.1
Official Full Name: UMP-CMP kinase;UMP-CMP kinase 2
Primary source: WormBase:WBGene00009575
Locus tag: CELE_F40F8.1
See related: AllianceGenome:WB:WBGene00009575
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables UMP kinase activity. Involved in UDP biosynthetic process. Predicted to be active in cytoplasm and nucleus. Is expressed in head; hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F40F8.1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (11127664..11129267)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F40F8.1 (e-PCR)
- UniSTS:316795

F40F8.9 (e-PCR)
- UniSTS:316798

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables (d)CMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables (d)CMP kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CMP kinase activity	IEA Inferred from Electronic Annotation more info
enables UMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UMP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables UMP kinase activity	IEA Inferred from Electronic Annotation more info
enables UMP/dUMP kinase activity	IEA Inferred from Electronic Annotation more info
enables dCMP kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UMP-CMP kinase;UMP-CMP kinase 2

NP_001300543.1

Confirmed by transcript evidence

NP_001366761.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11127664..11129267

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001313614.4 → NP_001300543.1 UMP-CMP kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARK6

Conserved Domains (2) summary

cd01428
Location:41 → 214

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01359
Location:41 → 223

UMP_CMP_kin_fam; UMP-CMP kinase family
NM_001381589.2 → NP_001366761.1 UMP-CMP kinase 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20230

Conserved Domains (1) summary

TIGR01359
Location:4 → 186

UMP_CMP_kin_fam; UMP-CMP kinase family