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    nas-36 Zinc metalloproteinase nas-36 [ Caenorhabditis elegans ]

    Gene ID: 172506, updated on 9-Dec-2024

    Summary

    Official Symbol
    nas-36
    Official Full Name
    Zinc metalloproteinase nas-36
    Primary source
    WormBase:WBGene00003552
    Locus tag
    CELE_C26C6.3
    See related
    AllianceGenome:WB:WBGene00003552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in molting cycle. Predicted to be located in extracellular region. Is expressed in hypodermal cell and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See nas-36 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (7527224..7531715)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Guanine nucleotide-binding protein G(o) subunit alpha Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Transcription factor dcp-66 Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in molting cycle, collagen and cuticulin-based cuticle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Zinc metalloproteinase nas-36
    NP_492109.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7527224..7531715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059708.4NP_492109.2  Zinc metalloproteinase nas-36 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492109.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18206
      Conserved Domains (4) summary
      smart00042
      Location:380478
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00209
      Location:510556
      TSP1; Thrombospondin type 1 repeats
      cd04280
      Location:140320
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:134323
      Astacin; Astacin (Peptidase family M12A)