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    mcm-6 DNA replication licensing factor mcm-6 [ Caenorhabditis elegans ]

    Gene ID: 176385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcm-6
    Official Full Name
    DNA replication licensing factor mcm-6
    Primary source
    WormBase:WBGene00003158
    Locus tag
    CELE_ZK632.1
    See related
    AllianceGenome:WB:WBGene00003158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication. Predicted to be part of MCM complex. Predicted to be active in nucleus. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mcm-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (9794367..9798644)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Apolipoprotein A1/A4/E domain protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Serpentine receptor class XA 10 Neighboring gene Uncharacterized protein Neighboring gene Serine/threonine-protein kinase RIO3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. Woodward AM, et al. J Cell Biol, 2006 Jun 5. PMID 16754955, Free PMC Article
    2. Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans. Piano F, et al. Curr Biol, 2002 Nov 19. PMID 12445391
    3. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development. Wang X, et al. Biochem Biophys Res Commun, 2007 Aug 10. PMID 17568563
    4. Http://C. elegans: mining the functional genomic landscape. Kim SK. Nat Rev Genet, 2001 Sep. PMID 11533717
    5. Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development. Yanagi K, et al. J Biol Chem, 2005 May 20. PMID 15811859

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to single-stranded 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor mcm-6
    NP_001023011.1
    • Confirmed by transcript evidence
    NP_001379433.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9794367..9798644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027840.6 → NP_001023011.1  DNA replication licensing factor mcm-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34647, Q5FC84
      Conserved Domains (3) summary
      smart00350
      Location:119 → 660
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:23 → 138
      MCM_N; MCM N-terminal domain
      cl21455
      Location:448 → 535
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001392181.1 → NP_001379433.1  DNA replication licensing factor mcm-6 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd17757
      Location:55 → 364
      MCM6; DNA replication licensing factor Mcm6
      pfam18263
      Location:416 → 513
      MCM6_C; MCM6 C-terminal winged-helix domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34647.1

    Gene LinkOut

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