nhx-2 Na(+)/H(+) exchanger protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhx-2
Official Full Name: Na(+)/H(+) exchanger protein 2
Primary source: WormBase:WBGene00003730
Locus tag: CELE_B0495.4
See related: AllianceGenome:WB:WBGene00003730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sodium:proton antiporter activity. Involved in several processes, including determination of adult lifespan; positive regulation of growth rate; and regulation of nematode pharyngeal pumping. Located in apical plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; congestive heart failure; and end stage renal disease. Orthologous to several human genes including SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhx-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (7690711..7693957, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pbo-1 regulates the membrane localization and activity of NHX-2/-7 in C.elegans.
Title: Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans.
RNA interference of nhx-2 reduces the basal pH of the intestinal cells, reduces the rate of proton movement between the lumen and the cytoplasm during defecation, and extends the defecation period.
Title: Oscillatory transepithelial H(+) flux regulates a rhythmic behavior in C. elegans.
data demonstrate a functional role for Na+/H+ exchanger, restricted to apical membrane of intestinal cells(NHX-2) in nutrient absorption in vivo and lays the groundwork for examining integrated acid-base physiology in a non-mammalian model organism
Title: A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0495.4 (e-PCR)
- UniSTS:308860

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of pH	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Na(+)/H(+) exchanger protein 2

NP_495614.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7690711..7693957 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063213.8 → NP_495614.4 Na(+)/H(+) exchanger protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495614.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09432, Q8T5S1

Conserved Domains (1) summary

pfam00999
Location:103 → 455

Na_H_Exchanger; Sodium/hydrogen exchanger family