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    vps-15 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 174827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-15
    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00014151
    Locus tag
    CELE_ZK930.1
    See related
    AllianceGenome:WB:WBGene00014151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in late endosome to vacuole transport; pexophagy; and protein targeting to vacuole. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in late endosome and nucleus-vacuole junction. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-15 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (11908725..11915852, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C4H2-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene RGS domain-containing protein Neighboring gene High mobility group protein hmg-12 Neighboring gene C2H2-type domain-containing protein;Zinc finger transcription factor lin-29 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. Liu J, et al. J Cell Biol, 2018 Jan 2. PMID 29092895, Free PMC Article
    2. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Swords SB, et al. Autophagy, 2024 Apr. PMID 37942902, Free PMC Article
    3. Autophagy during ageing - from Dr Jekyll to Mr Hyde. Wilhelm T, et al. FEBS J, 2018 Jul. PMID 29630766
    4. Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. Silhankova M, et al. EMBO J, 2010 Dec 15. PMID 21076391, Free PMC Article
    5. Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans. Konstantinidis G, et al. Cells, 2021 Mar 21. PMID 33800981, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pexophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus-vacuole junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_001254322.1
    • Confirmed by transcript evidence
    NP_001254323.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11908725..11915852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267393.3 → NP_001254322.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254322.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23669
      Conserved Domains (6) summary
      smart00320
      Location:957 → 996
      WD40; WD40 repeats
      COG0515
      Location:30 → 382
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      COG2319
      Location:948 → 1053
      WD40; WD40 repeat [General function prediction only]
      cd13980
      Location:20 → 324
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:540 → 565
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:971 → 1017
      7WD40; WD40 repeat [structural motif]

    2. NM_001267394.3 → NP_001254323.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P864
      Conserved Domains (3) summary
      smart00320
      Location:48 → 87
      WD40; WD40 repeats
      COG2319
      Location:39 → 144
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:62 → 108
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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