mdh-1 Malate dehydrogenase, cytoplasmic [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mdh-1
Official Full Name: Malate dehydrogenase, cytoplasmic
Primary source: WormBase:WBGene00018491
Locus tag: CELE_F46E10.10
See related: AllianceGenome:WB:WBGene00018491
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables L-malate dehydrogenase (NAD+) activity. Involved in malate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 88. Orthologous to human MDH1 (malate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mdh-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (6515283..6516526, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases.
Title: Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F46E10.10 (e-PCR)
- UniSTS:317374

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-malate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables malate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oxaloacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Malate dehydrogenase, cytoplasmic

NP_504656.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6515283..6516526 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072255.4 → NP_504656.1 Malate dehydrogenase, cytoplasmic [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504656.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9UAV5

Conserved Domains (2) summary

cd01336
Location:3 → 328

MDH_cytoplasmic_cytosolic; Cytoplasmic and cytosolic Malate dehydrogenases

PRK05442
Location:1 → 325

PRK05442; malate dehydrogenase; Provisional