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    glh-3 ATP-dependent RNA helicase glh-3 [ Caenorhabditis elegans ]

    Gene ID: 172245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glh-3
    Official Full Name
    ATP-dependent RNA helicase glh-3
    Primary source
    WormBase:WBGene00001600
    Locus tag
    CELE_B0414.6
    See related
    AllianceGenome:WB:WBGene00001600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DEAD/H-box RNA helicase binding activity and JUN kinase binding activity. Predicted to be involved in germ cell development. Located in P granule. Is expressed in gonad. Orthologous to human DDX4 (DEAD-box helicase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glh-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (5792321..5795114, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Runt-related transcription factor rnt-1 Neighboring gene Cytoplasmic polyadenylation element-binding protein 3 Neighboring gene Protein kinase domain-containing protein Neighboring gene Serpentine Receptor, class Z Neighboring gene Vacuolar protein sorting-associated protein 51 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins. Spike C, et al. Genetics, 2008 Apr. PMID 18430929, Free PMC Article
    2. The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein. Smith P, et al. Dev Biol, 2002 Nov 15. PMID 12435362
    3. Cloning and expression analysis of pos-1 in the nematodes Caenorhabditis briggsae and Caenorhabditis remanei. Konwerski J, et al. Dev Dyn, 2005 Jul. PMID 15880508
    4. Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans. Kuznicki KA, et al. Development, 2000 Jul. PMID 10851135
    5. ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. Andralojc KM, et al. PLoS Genet, 2017 Feb. PMID 28182654, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DEAD/H-box RNA helicase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables JUN kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamete generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase glh-3
    NP_491681.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5792321..5795114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059280.5 → NP_491681.1  ATP-dependent RNA helicase glh-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01836
      Conserved Domains (3) summary
      PRK11192
      Location:300 → 719
      PRK11192; ATP-dependent RNA helicase SrmB; Provisional
      cd00268
      Location:300 → 509
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:537 → 658
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01836.1

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