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    lgc-53 Neur_chan_memb domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgc-53
    Official Full Name
    Neur_chan_memb domain-containing protein
    Primary source
    WormBase:WBGene00020657
    Locus tag
    CELE_T21F2.1
    See related
    AllianceGenome:WB:WBGene00020657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgc-53 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (16711681..16720670)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Histone deacetylase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antagonistic effect of dopamine structural analogues on human GABAρ1 receptor. Alaniz-Palacios A, et al. Sci Rep, 2017 Dec 12. PMID 29234054, Free PMC Article
    2. Fast phasic release properties of dopamine studied with a channel biosensor. Kress GJ, et al. J Neurosci, 2014 Aug 27. PMID 25164674, Free PMC Article
    3. Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Ringstad N, et al. Science, 2009 Jul 3. PMID 19574391, Free PMC Article
    4. Amphetamine potentiates the effects of β-phenylethylamine through activation of an amine-gated chloride channel. Safratowich BD, et al. J Neurosci, 2014 Mar 26. PMID 24672014, Free PMC Article
    5. Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. Barros AG, et al. PLoS One, 2014. PMID 24465759, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neur_chan_memb domain-containing protein
    NP_001379650.1
    • Confirmed by transcript evidence
    NP_741945.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16711681..16720670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171812.7 → NP_741945.3  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741945.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYN9
      Conserved Domains (3) summary
      TIGR00860
      Location:87 → 489
      LIC; Cation transporter family protein
      pfam02931
      Location:88 → 294
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:302 → 486
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001392910.1 → NP_001379650.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PJ95
      Conserved Domains (1) summary
      TIGR00860
      Location:1 → 270
      LIC; Cation transporter family protein
    Nucleotide Protein
    Heading Accession and Version

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