fkh-6 Forkhead transcription factor fkh-6 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: fkh-6
Official Full Name: Forkhead transcription factor fkh-6
Primary source: WormBase:WBGene00001438
Locus tag: CELE_B0286.5
See related: AllianceGenome:WB:WBGene00001438
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sequence-specific DNA binding activity. Involved in male germ-line sex determination and male gonad development. Predicted to be located in nucleus. Is expressed in gonad; somatic gonad precursor; and in male. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4 and otosclerosis 11. Orthologous to several human genes including FOXI2 (forkhead box I2) and FOXI3 (forkhead box I3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male germ-line sex determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_494775.1

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The following sections contain reference sequences that belong to a specific genome build. Explain