dpy-7 Cuticle collagen dpy-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpy-7
Official Full Name: Cuticle collagen dpy-7
Primary source: WormBase:WBGene00001069
Locus tag: CELE_F46C8.6
See related: AllianceGenome:WB:WBGene00001069
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Located in annular furrow extracellular matrix. Is expressed in several structures, including P1; P10; P11; cuticle; and hypodermis. Used to study skin disease. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dpy-7 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 2

Sequence:: Chromosome: X; NC_003284.9 (7536467..7537792, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F46C8.6 (e-PCR)
- UniSTS:312336

F46C8.7 (e-PCR)
- UniSTS:306382

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural constituent of collagen and cuticulin-based cuticle	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cuticle	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in annular furrow extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen and cuticulin-based cuticle extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cuticle collagen dpy-7

NP_509274.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7536467..7537792 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076873.7 → NP_509274.1 Cuticle collagen dpy-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509274.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34688

Conserved Domains (2) summary

pfam01391
Location:145 → 203

Collagen; Collagen triple helix repeat (20 copies)

smart01088
Location:11 → 62

Col_cuticle_N; Nematode cuticle collagen N-terminal domain