agxt-1 Alanine--glyoxylate aminotransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: agxt-1
Official Full Name: Alanine--glyoxylate aminotransferase
Primary source: WormBase:WBGene00011767
Locus tag: CELE_T14D7.1
See related: AllianceGenome:WB:WBGene00011767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables alanine-glyoxylate transaminase activity. Involved in glycine biosynthetic process, by transamination of glyoxylate. Located in mitochondrion. Is expressed in body wall musculature and intestine. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See agxt-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (8845598..8848902)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1.
Title: Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T14D7.1 (e-PCR)
- UniSTS:310842

STS2-10 (e-PCR)
- UniSTS:241764

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-serine-pyruvate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-glyoxylate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-glyoxylate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables alanine-glyoxylate transaminase activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycine biosynthetic process, by transamination of glyoxylate	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine biosynthetic process, by transamination of glyoxylate	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Alanine--glyoxylate aminotransferase

NP_495885.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8845598..8848902

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063484.7 → NP_495885.1 Alanine--glyoxylate aminotransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495885.1

Status: REVIEWED

UniProtKB/TrEMBL

Q94055

Conserved Domains (2) summary

TIGR03301
Location:42 → 381

PhnW-AepZ; 2-aminoethylphosphonate aminotransferase

cl18945
Location:42 → 382

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...