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    acs-11 fatty Acid CoA Synthetase family [ Caenorhabditis elegans ]

    Gene ID: 173820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-11
    Official Full Name
    fatty Acid CoA Synthetase family
    Primary source
    WormBase:WBGene00018269
    Locus tag
    CELE_F41C3.3
    See related
    AllianceGenome:WB:WBGene00018269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in IRE1-mediated unfolded protein response. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (4742137..4745280)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine carboxypeptidase ctsa-1.1 Neighboring gene putative Golgi transport protein 1 Neighboring gene MFS domain-containing protein Neighboring gene Exocyst complex component Sec8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans. Ma X, et al. J Hazard Mater, 2022 Jan 5. PMID 34325294
    2. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article
    3. Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans. Mangu JCK, et al. Sci Total Environ, 2022 Aug 20. PMID 35460794
    4. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
    5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables medium-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty Acid CoA Synthetase family
    NP_494848.3
    • Product from WormBase gene class acs;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4742137..4745280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062447.10 → NP_494848.3  fatty Acid CoA Synthetase family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494848.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20264
      Conserved Domains (2) summary
      PRK07514
      Location:34 → 505
      PRK07514; malonyl-CoA synthase; Validated
      cd05941
      Location:37 → 493
      MCS; Malonyl-CoA synthetase (MCS)
    Nucleotide Protein
    Heading Accession and Version

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