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    glr-5 GLutamate Receptor family (AMPA) [ Caenorhabditis elegans ]

    Gene ID: 179251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glr-5
    Official Full Name
    GLutamate Receptor family (AMPA)
    Primary source
    WormBase:WBGene00001616
    Locus tag
    CELE_ZC196.7
    See related
    AllianceGenome:WB:WBGene00001616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in neurons. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glr-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (8716495..8720516)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Saposin B-type domain-containing protein;Transposase Neighboring gene Tandem-repeating region of mucin epiglycanin-like domain-containing protein Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene dietary restriction over expressed

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signal Decoding for Glutamate Modulating Egg Laying Oppositely in Caenorhabditis elegans under Varied Environmental Conditions. Wen X, et al. iScience, 2020 Oct 23. PMID 33089099, Free PMC Article
    2. Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron. Zou W, et al. Nat Commun, 2018 Oct 17. PMID 30333484, Free PMC Article
    3. The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum. Shim J, et al. Mol Biol Cell, 2004 Nov. PMID 15317844, Free PMC Article
    4. Glutamate receptor channel signatures. Sprengel R, et al. Trends Pharmacol Sci, 2001 Jan. PMID 11165660
    5. Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. Brockie PJ, et al. J Neurosci, 2001 Mar 1. PMID 11222641, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GLutamate Receptor family (AMPA)
    NP_505244.1
    • Product from WormBase gene class glr;
      Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8716495..8720516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072843.6 → NP_505244.1  GLutamate Receptor family (AMPA) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01623
      Conserved Domains (4) summary
      cd06381
      Location:26 → 418
      PBP1_iGluR_delta_like; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of an orphan family of delta receptors, GluRdelta1 and GluRdelta2
      cd13714
      Location:438 → 819
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:568 → 855
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:38 → 377
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version

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