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    cadA lysine decarboxylase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948643, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cadA
    Official Full Name
    lysine decarboxylase 1
    Primary source
    ECOCYC:EG10131
    Locus tag
    b4131
    See related
    ASAP:ABE-0013526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4125; ldcI
    Summary
    Induction of the cadAB operon under acidic conditions and in the presence of lycine neutralized extracellualr environment and enabled production of CO(2); production of cadaverine and aminopropylcadaverine instead of putrescine and spermidine also resulted. cadAB operon induction also generated a proton motive force. [More information is available at EcoGene: EG10131]. CadA, a lysine decarboxylase enzyme, is part of the lysine-dependent acid resistance system 4 (AR4) which confers resistance to weak organic acids produced during carbohydrate fermentation under conditions of anaerobiosis and phosphate starvation. [More information is available at EcoCyc: EG10131].
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    Genomic context

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    Sequence:
    NC_000913.3 (4356470..4358617, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase Neighboring gene dipeptide/tripeptide:H(+) symporter DtpC Neighboring gene lysine:cadaverine antiporter Neighboring gene DNA-binding transcriptional activator CadC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhancement of the thermal and alkaline pH stability of Escherichia coli lysine decarboxylase for efficient cadaverine production. Kou F, et al. Biotechnol Lett, 2018 Apr. PMID 29349625
    2. Effects of cadA gene on cell division phenotype. Mandić A. Med Pregl, 1998 Jan-Feb. PMID 9531770
    3. "Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Maurelli AT, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520472, Free PMC Article
    4. The Escherichia coli flagellar transcriptional activator flhD regulates cell division through induction of the acid response gene cadA. Prüss BM, et al. J Bacteriol, 1997 Jun. PMID 9171439, Free PMC Article
    5. Effect of chelating agents and respiratory inhibitors on regulation of the cadA gene in Escherichia coli. Reams SG, et al. Arch Microbiol, 1997 Apr. PMID 9075621

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics.
      Title: Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics.
    2. To enhance the thermal and alkaline pH stability of the lysine decarboxylase from Escherichia coli (CadA) by engineering the decameric interface and explore its potential for industrial applications
      Title: Enhancement of the thermal and alkaline pH stability of Escherichia coli lysine decarboxylase for efficient cadaverine production.
    3. Data show that the RavA structure provides insights into how five RavA hexamers interact with two LdcI/CadA decamers to form the RavA-LdcI/CadA cage-like structure.
      Title: Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity.
    4. N-terminus verified by Edman degradation on complete protein
      Title: Characterization of a second lysine decarboxylase isolated from Escherichia coli.
    5. Helps phosphate starved cells tolerate production of fermentation acids under anaerobic conditions.
      Title: The lysine decarboxylase CadA protects Escherichia coli starved of phosphate against fermentation acids.
    6. The transcriptional activator CadC in Escherichia coli, a member of the ToxR-like proteins, activates transcription of the cadBA operon encoding the lysine decarboxylase CadA and the lysine-cadaverine antiporter CadB
      Title: CadC-mediated activation of the cadBA promoter in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lysine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lysine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysine decarboxylase 1
    NP_418555.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4356470..4358617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418555.1 lysine decarboxylase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418555.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3P5DXD7, A0A478LL36
      Conserved Domains (1) summary
      PRK15400
      Location:1 → 714
      PRK15400; lysine decarboxylase
    Nucleotide Protein
    Heading Accession and Version

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