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    npp-10 Nuclear pore complex protein Nup98 [ Caenorhabditis elegans ]

    Gene ID: 175852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-10
    Official Full Name
    Nuclear pore complex protein Nup98
    Primary source
    WormBase:WBGene00003796
    Locus tag
    CELE_ZK328.5
    See related
    AllianceGenome:WB:WBGene00003796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA binding activity. Involved in several processes, including mitotic chromosome centromere condensation; nuclear pore localization; and protein localization to organelle. Located in P granule; kinetochore; and nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (6013447..6019562, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein 26;SH3 domain-containing protein Neighboring gene Germ cell nuclear acidic-1 protein Neighboring gene Tr-type G domain-containing protein Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase cyk-3 Neighboring gene Putative T-box protein 7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved CRISPR/Cas9 knock-in efficiency via the self-excising cassette (SEC) selection method in C. elegans. Huang G, et al. MicroPubl Biol, 2021. PMID 34549176, Free PMC Article
    2. The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules. Voronina E, et al. Development, 2010 May. PMID 20335358, Free PMC Article
    3. The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans. Miwa T, et al. Genes Cells, 2022 Oct. PMID 35950937
    4. Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity. Schmidt HB, et al. Elife, 2015 Jan 6. PMID 25562883, Free PMC Article
    5. Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz C, et al. EMBO J, 2005 Oct 19. PMID 16193066, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in P granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic chromosome centromere condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear pore localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere tethering at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear pore cytoplasmic filaments IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear pore complex protein Nup98
    NP_001254934.1
    • Confirmed by transcript evidence
    NP_001367842.1
    • Confirmed by transcript evidence
    NP_498310.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6013447..6019562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379737.1 → NP_001367842.1  Nuclear pore complex protein Nup98 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D1MN48, G5EEH9, H2L014
      Conserved Domains (3) summary
      pfam04096
      Location:777 → 919
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:1259 → 1512
      Nup96; Nuclear protein 96
      pfam13634
      Location:237 → 334
      Nucleoporin_FG; Nucleoporin FG repeat region

    2. NM_065909.6 → NP_498310.3  Nuclear pore complex protein Nup98 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498310.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEH9
      Conserved Domains (2) summary
      pfam04096
      Location:779 → 919
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:214 → 322
      Nucleoporin_FG; Nucleoporin FG repeat region

    3. NM_001268005.2 → NP_001254934.1  Nuclear pore complex protein Nup98 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEH9
      Conserved Domains (2) summary
      pfam04096
      Location:781 → 921
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:216 → 324
      Nucleoporin_FG; Nucleoporin FG repeat region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEH9.1

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