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    gpa-5 Guanine nucleotide-binding protein alpha-5 subunit [ Caenorhabditis elegans ]

    Gene ID: 180527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpa-5
    Official Full Name
    Guanine nucleotide-binding protein alpha-5 subunit
    Primary source
    WormBase:WBGene00001667
    Locus tag
    CELE_F53B1.7
    See related
    AllianceGenome:WB:WBGene00001667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and phospholipase C-activating dopamine receptor signaling pathway. Located in axon; neuronal cell body; and synapse. Is expressed in amphid neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpa-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (2118894..2121061, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sphingomyelin synthase-related 1 Neighboring gene NAD(P)-binding domain-containing protein Neighboring gene Metallo-beta-lactamase domain-containing protein 1 Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegans. Lans H, et al. Genetics, 2004 Aug. PMID 15342507, Free PMC Article
    2. Signaling proteins that regulate NaCl [corrected] chemotaxis responses modulate longevity in C. elegans. Lans H, et al. Ann N Y Acad Sci, 2009 Jul. PMID 19686212
    3. Chemosensory signaling in C. elegans. Troemel ER. Bioessays, 1999 Dec. PMID 10580986
    4. The forkhead domain gene unc-130 generates chemosensory neuron diversity in C. elegans. Sarafi-Reinach TR, et al. Genes Dev, 2000 Oct 1. PMID 11018015, Free PMC Article
    5. Odour concentration-dependent olfactory preference change in C. elegans. Yoshida K, et al. Nat Commun, 2012 Mar 13. PMID 22415830

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Guanine nucleotide-binding protein alpha-5 subunit
    NP_508393.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2118894..2121061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075992.1 → NP_508393.1  Guanine nucleotide-binding protein alpha-5 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508393.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20701
      Conserved Domains (2) summary
      cd00066
      Location:34 → 379
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:13 → 383
      G_alpha; G protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20701.1

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