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    dut-1 dUTP diphosphatase [ Caenorhabditis elegans ]

    Gene ID: 172794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dut-1
    Official Full Name
    dUTP diphosphatase
    Primary source
    WormBase:WBGene00010609
    Locus tag
    CELE_K07A1.2
    See related
    AllianceGenome:WB:WBGene00010609
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dUTP diphosphatase activity and magnesium ion binding activity. Predicted to be involved in dUMP biosynthetic process and dUTP catabolic process. Is expressed in intestine. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dut-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (9585417..9587203)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein Neighboring gene Actin maturation protease Neighboring gene TransThyretin-Related family domain Neighboring gene TransThyretin-Related family domain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans. Miyaji M, et al. Sci Rep, 2018 Nov 13. PMID 30425296, Free PMC Article
    2. Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. Dengg M, et al. EMBO Rep, 2006 Oct. PMID 16964178, Free PMC Article
    3. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. Erdélyi P, et al. J Cell Sci, 2011 May 1. PMID 21502138, Free PMC Article
    4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dUTP diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dUTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dUTP diphosphatase
    NP_001021553.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9585417..9587203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026382.7 → NP_001021553.1  dUTP diphosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EET2
      Conserved Domains (1) summary
      TIGR00576
      Location:186 → 324
      dut; deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
    Nucleotide Protein
    Heading Accession and Version

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