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    efsc-1 Tr-type G domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    efsc-1
    Official Full Name
    Tr-type G domain-containing protein
    Primary source
    WormBase:WBGene00008133
    Locus tag
    CELE_C47B2.7
    See related
    AllianceGenome:WB:WBGene00008133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation elongation factor activity. Involved in selenocysteine incorporation. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See efsc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (12978839..12982451)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Eukaryotic translation initiation factor 6 Neighboring gene UDP-glucose 4-epimerase Neighboring gene Peroxisomal biogenesis factor 11 Neighboring gene RNA-binding S4 domain-containing protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. Fagegaltier D, et al. EMBO J, 2000 Sep 1. PMID 10970870, Free PMC Article
    2. Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans. Stenvall J, et al. Proc Natl Acad Sci U S A, 2011 Jan 18. PMID 21199936, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in selenocysteine incorporation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tr-type G domain-containing protein
    NP_493275.1
    • Confirmed by transcript evidence
    NP_493276.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12978839..12982451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060874.3 → NP_493275.1  Tr-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493275.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62108
      Conserved Domains (2) summary
      COG3276
      Location:14 → 493
      SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
      cl38936
      Location:15 → 189
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_060875.6 → NP_493276.1  Tr-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62109
      Conserved Domains (4) summary
      TIGR00475
      Location:14 → 275
      selB; selenocysteine-specific elongation factor SelB
      COG5192
      Location:387 → 449
      BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]
      cd03696
      Location:161 → 241
      SelB_II; Domain II of elongation factor SelB
      cd04094
      Location:253 → 346
      eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    Nucleotide Protein
    Heading Accession and Version

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