Lin28b lin-28 homolog B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lin28bprovided by MGI
Official Full Name: lin-28 homolog Bprovided by MGI
Primary source: MGI:MGI:3584032
See related: Ensembl:ENSMUSG00000063804 AllianceGenome:MGI:3584032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lin-28.2; 2810403D23Rik; D030047M17Rik
Summary: Predicted to enable mRNA binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in RNA metabolic process; positive regulation of miRNA catabolic process; and regulation of gene expression. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and lumbar dorsal root ganglion. Used to study neuroblastoma. Orthologous to human LIN28B (lin-28 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 3.2), liver E14 (RPKM 3.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B2; 10 23.5 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (45252713..45362410, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (45376617..45486314, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
Title: The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
Title: Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
Title: Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
LIN28B induces a differentiation program through CDX2 in colon cancer.
Title: LIN28B induces a differentiation program through CDX2 in colon cancer.
Lin28 paralogs regulate lung branching morphogenesis.
Title: Lin28 paralogs regulate lung branching morphogenesis.
Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation.
Title: Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation.
LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
Title: LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
A B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to let-7 gene expression.
Title: An ontogenetic switch drives the positive and negative selection of B cells.
lin28B is a crucial modulator determining the fate of transplanted mesenchymal stem cells by regulating IGF-2-associated pathways and thereby enhancing their protective effects against AD
Title: Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2.
The Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19(-/-) adult mice.
Title: Lin28b controls a neonatal to adult switch in B cell positive selection.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236345

D10Ertd755e (e-PCR), detects polymorphism
- UniSTS:167038

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in RNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in RNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in miRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of pre-miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of primary miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein lin-28 homolog B

Names: lin-28B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031772.2 → NP_001026942.1 protein lin-28 homolog B

See identical proteins and their annotated locations for NP_001026942.1

Status: VALIDATED

Source sequence(s)

BC089037, DQ127225

Consensus CDS

CCDS35895.1

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Related

ENSMUSP00000078361.7, ENSMUST00000079390.7

Conserved Domains (2) summary

PTZ00368
Location:151 → 187

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:29 → 99

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

45252713..45362410 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243182.4 → XP_011241484.1 protein lin-28 homolog B isoform X2

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:176 → 212

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:54 → 124

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_011243180.4 → XP_011241482.1 protein lin-28 homolog B isoform X1

See identical proteins and their annotated locations for XP_011241482.1

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:183 → 219

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:61 → 131

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_036155874.1 → XP_036011767.1 protein lin-28 homolog B isoform X3

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:161 → 197

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:39 → 109

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_011243183.4 → XP_011241485.1 protein lin-28 homolog B isoform X3

See identical proteins and their annotated locations for XP_011241485.1

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:161 → 197

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:39 → 109

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_011243185.4 → XP_011241487.1 protein lin-28 homolog B isoform X3

See identical proteins and their annotated locations for XP_011241487.1

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:161 → 197

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:39 → 109

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_011243186.3 → XP_011241488.1 protein lin-28 homolog B isoform X3

See identical proteins and their annotated locations for XP_011241488.1

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:161 → 197

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:39 → 109

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_036155873.1 → XP_036011766.1 protein lin-28 homolog B isoform X1

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:183 → 219

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:61 → 131

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_011243187.3 → XP_011241489.1 protein lin-28 homolog B isoform X4

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:160 → 196

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:38 → 108

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_011243188.1 → XP_011241490.1 protein lin-28 homolog B isoform X5

See identical proteins and their annotated locations for XP_011241490.1

UniProtKB/Swiss-Prot

Q3UZC6, Q3V444, Q45KJ6

Conserved Domains (2) summary

PTZ00368
Location:151 → 187

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

cd04458
Location:29 → 99

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001033152.1: Suppressed sequence

Description

NM_001033152.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.